LDN • Compounded

Low dose naltrexone, compounded the way your prescriber wrote it.

Naltrexone is FDA-approved at 50mg. The doses your provider may prescribe for autoimmune, chronic pain, or inflammation conditions (typically 0.5–4.5mg) don't exist commercially. They have to be compounded — and that's what we do.

  • Custom strengths from 0.5mg through 6mg
  • Capsule or topical cream, your prescriber's call
  • Slow-release options available on request
  • Same or next business day turnaround
Pharmacy technician in sterile scrubs working in the Magnolia Pharmacy compounding lab

How LDN works

A different mechanism at a different dose.

At low doses, naltrexone briefly blocks opioid receptors at night. The body responds by upregulating endogenous endorphin and enkephalin production over the following hours.

Many prescribers and researchers believe this immune-modulating effect is what may help patients with autoimmune and inflammatory conditions feel better — without the sedation or dependence risk of stronger medications.

Common titration schedule

  1. 1Weeks 1–2 — 1.5mg at bedtime
  2. 2Weeks 3–4 — 3.0mg at bedtime
  3. 3Week 5+ — 4.5mg at bedtime (target dose)
  4. 4Adjust up or down based on response

Example schedule for illustration only. Your prescriber will design your protocol.

Conditions prescribers commonly use LDN for

LDN is being explored across a wide range of inflammatory and autoimmune conditions. Talk to your prescriber about whether it might support your situation.

Autoimmune Conditions

Hashimoto's, lupus, rheumatoid arthritis, psoriasis, MS.

Chronic Pain & Fibromyalgia

Widespread pain, tender points, post-exertional flares.

Long COVID & Chronic Fatigue

Persistent fatigue, brain fog, post-exertional malaise.

Mood & Cognition

Depression, anxiety, and cognitive symptoms tied to inflammation.

IBS & Crohn's

Inflammatory bowel symptoms and gut-immune dysregulation.

Sleep & Recovery

Poor recovery, restless sleep, daytime fatigue.

Steve Hoffart, PharmD

The Trusted Pharmacist

Steve Hoffart, PharmD trains prescribers nationwide on compounded LDN.

"Every formulation that leaves our lab is one we'd give our own family."

Steve Hoffart, PharmD · Founder

Steve has spent the last decade educating providers on LDN protocols, titration strategies, and the practical reality of compounding it accurately. When your script lands in our lab, it's getting weighed and verified by people who know exactly what it's for.

20+

Years compounding for Houston families

1 of few

Sterile-cleanroom 503A pharmacies in TX

100%

Pharmacist-reviewed formulations

Meet the team

From script to first dose — in days, not weeks.

Step 1

Send us your script

Your prescriber faxes, e-prescribes, or sends through our portal.

Step 2

We verify the dose

Pharmacist reviews titration plan, flags interactions, and confirms strength.

Step 3

We compound it

USP 795 compounding in our on-site Magnolia lab — typically same business day.

Step 4

Ship or pick up

Texas-wide shipping or local pickup. Refills auto-tracked in our portal.

Frequently Asked Questions

Ready when you are

Need LDN compounded? We're ready.

Whether you're a patient looking for a pharmacy that knows LDN, or a prescriber who needs a reliable compounding partner — let's talk.

Talk to a pharmacist Prescriber portal

Local pickup in Magnolia, TX · Shipping across Texas & most states.

CCE-Accredited Compounding Pharmacy

USP 795 & 797 Sterile Compliant

PCCA Pharmacist of the Year

Serving Houston Since 2002

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